Estrogen monotherapy levels The claimed estradiol levels are low (median 36 pg/mL), so feminization doesn't seem too likely even if the median testosterone level of 20 ng/dL is correct. never Spiro) unless I HAVE to. , 150–300 mg/day) is a possible approach The primary outcome will be testosterone level at three month follow‐up. DIY HRT 20+ years ago (before internet pharmacies were common) tended to not use anti androgens because while you could get syringes of feminizing hormones from your local hard drug dealer, After three months on estrogen monotherapy (6 weeks of 4mg sublingual and 6 weeks of 6mg buccal), my levels are: Testosterone - 36 (Suppression) Estrogen - 97 The best part is that these levels were taken a full 10 hours after my last dose, so they are below trough levels. HRT guides ignore trans women and science with no mention of high level estrogen monotherapy witch has proven that estrogen only therapy can adequately and completely bring testosterone levels for trans women into the ideal physiological range; in addition - high levels of estrogen treatment exceeding 100 and 200 mg on occasion with healthy Now if injections are the most available and cost effective stuff you can get hold off then monotherapy makes sense over the alternatives, because the concentration they are produced to means that doses are a small volume anyway and you will probably naturally hit close to needed levels of T suppression just trying to keep a manageable trough I am wondering if anyone has been on estrogen without t-blockers and could tell me exactly what effects they Now I’m 100% convinced to switch to E monotherapy only. , breast atrophy, loss For instance, it allows for easy and inexpensive attainment of higher estradiol levels that can be useful in transfeminine people for achieving better testosterone suppression. This is in contrast to therapies that act by suppressing androgen production and levels. I take 3 mg per day, buccally, 1 mg every 8 hours. The second link sends to DrWillPowers, which uses Estrogen Monotherapy, which evidently needs higher levels since there is no T-blocker. c Much lower doses of transdermal estradiol can be used in the case of genital application relative to conventional skin sites (potentially e. Home; My understanding is that reducing the prolactinoma's envolvement in production should not effect Estrogen monotherapy . Estrogen monotherapy or co-treatment of ADT may serve as an alternative approach (17, 18, 19), while beneficial effects on bone are known for (21, 25) or by estrogen monotherapy reaching castration levels of testosterone . *bear in mind though by this point I'd spent over £1,000 to get appointments to get T suppression from spironolactone or from estrogen (monotherapy) My levels are good, with 25ng/dL T and 314pg/mL E2 last time I got my blood tested. Since levels of estrogen peak and then decline with injections and transdermal (patch/cream) formulations, it can also be harder for doctors to figure out the right level to prescribe. i got breast developement but i got too pilosity ( body hair) on masculine area ( That's called monotherapy, and is generally only achievable with injections and sometimes transdermal applications. 3 to 1. ‍ There are multiple options to microdose While surgical menopause is associated with an abrupt decline in estrogen levels, it also leads to rapid declines in testosterone and progesterone levels. I'm trying to decide between Estrogen monotherapy and Estrogen plus a testosterone blocker. the doctor hates u lol 😂 i went to 4mg sublingual daily till i switched to injections and oh boy injections make ur estrogen levels way higher My regimen has been estrogen and progesterone monotherapy from the start of my hrt, the first year my e levels were too low to be therapeutic (135pmol/l - 270pmol/l) due to use of 50mcg, then 75mcg then 100mcg estradot patches til 6 months, then 1mg progynova til month 9, 2mg progynova til month 12 and then 2x2mg progynova from month 12-15, HRT guides ignore trans women and science with no mention of high level estrogen monotherapy witch has proven that estrogen only therapy can adequately and completely bring testosterone levels for trans women into the ideal physiological range; in addition - high levels of estrogen treatment exceeding 100 and 200 mg on occasion with healthy The degree of breast development is dependent on many factors, but most transfeminine patients experience modest breast development (average cup size A, or developmental Tanner stage 2 to 3). 0000-0001-5706-0571 and expression levels of the D-type cyclins that complex and interact with CDK4/6 are controlled by growth factor DIY HRT Journal – Estrogen Monotherapy Background Measurements: 178cm, 67kg, AMAB Age Metabolic rate: Relatively high metabolic rate, moderate level of physical activity (1-2 times of exercise/week) Body type: Relatively muscular, Low body fat Figs Figs6 6 and and7 7 illustrate that increasing dosage leads to eliminating LH surge and decreasing fluctuation in P 4 level. I asked if oral monotherapy was safe despite the impact on the liver it can have A simulator for estradiol levels with injectable estradiol esters. But your DHT is still reduced. I found that sublingual, it would dissolve in minutes and I'd taste a little. 6 to 1. Lack of availability. Some people have a higher metabolisation of estrone on pills, which is a weak estrogen and which People who are assigned male at birth (AMAB) will have higher testosterone levels and lower estradiol (estrogen) levels compared to those assigned female at birth (AFAB). Many people self dosing E monotherapy or following Powers method aim for that, but doctors who are more traditional usually target 100-200 pg/ml of E. The risks of issues with cancer and liver are Estrogen has an anti-androgenic property by reducing the endogenous testosterone via negative feed-back on hypothalamus-pituitary levels. The sublingual route is generally safer for blood and liver as compared to oral, If you are doing monotherapy, you will probably need quite a high estradiol level to suppress testosterone, which is why people doing monotherapy commonly use injections rather than oral estradiol. Oestrogens can be administered as either oral Estrogen-only therapy reduced the testosterone, luteinizing hormone and follicle-stimulating hormone levels from 731. The Effect of HT on Mood during the Menopausal Transition. Additional comment actions. Oral hormone replacement therapy (HRT) increases blood coagulability by increasing clotting factor levels and decreasing antithrombin activity . And there are some people who are happy with how their bodies turn out despite not reaching the targeted estrogen levels. In progesterone monotherapy, ovulation is suppressed between doses 3. From what I've been reading your test levels will decline to pre-therapy more than likely, but since hcg doesn't send a negative feedback loop to the HPTA (so long as estrogen is in check while on it) recovery is much easier. 79-0. 36ml weekly, and Spiro is 200mg. Abstract Estrogen monotherapy (EM) was defined as at least one estrogen claim without any progesterone claims 6 months prior to diagnosis. Only one study provided a head-to-head comparison of two different antiandrogens . I take a relatively high amount of estradiol daily, and historically, even post surgery, I have had testosterone levels just above normal female range (ironically, these are higher than before surgery, when I was just doing E monotherapy) A table of hormone levels for reference by transgender people. If you're going to go down this route regardless, 1mg - 2mg of exemestane per day should (cautiously) considered as it still reduces estradiol significantly; the standard 12. As your levels rise, your testosterone levels should start to fall. Author links open overlay stage, treatment, and survival, along with the SEER site of diagnosis, demographic data, and selected census tract-level information for 26% of the United States population. There is evidence to suggest that women between the ages of menstruation onset and menopause are at increased risk for mood disorders (31, 32). Hormone therapy is a safe and beneficial option for most women over 65, according to a new study. I am hoping this high dose will be sufficient to lower my T to castrate levels in order to avoid having to take any anti-androgens. Took a while to bring my T down but now everything is in healthy range. I'm a bit confused as far as levels of estrogen since Dr Powers says that 100 is the ideal for estrogen on trans women. Imlunestrant is a next-generation oral selective estrogen receptor (ER) degrader designed to deliver continuous ER target inhibition, including in ESR1-mutant breast cancer. Monotherapy used to be fairly common, 30+ years ago. It has generally been smooth sailing - I get blood work every six to twelve months and each time, my test levels are in the 550+ ng/dL range, estrogen in the low to mid twenties, no side effects, feeling great generally. 2mg a day is not a lot, it will increase your E levels slightly, you need to suppress testosterone. As for results, fantastic Generally, “males”2 tend to have higher androgen levels, and “females”2 tend to have higher levels of estrogens and progestagens. Either by having a dedicated blocker medication, or high enough estrogen levels. Everyone has a balance of testosterone and estrogen. That means I'm probably within range on both testosterone and estrogen! The Mueller study that looked at 10 mg of estradiol valerate IM every 10 days with levels at 12 months and 24 months was confounded by the fact that the protocol allowed for extending the injection cycle to 14 days, but also reported trough levels. but I still 100% want to keep off of anti-androgens until I have higher E levels and have spent a full year on estrogen first. With injections, your levels acts like a decaying curve meaning your levels will be at its highest on the day of injections and your levels slowly decays over time. Impact of estrogen monotherapy on survival in women with stage III-IV non-small cell lung cancer. This results in a decrease in bone mineral density (BMD) and an increase in fractures. I have been told low estrogen can cause this and since my doctor is refusing to increase my dose I have decided to diy and as such I would like to know an average dose for Estradiol. Also labs should only ever be Using estrogen pills once a day can make for a spike and a low later. . [since last dose] This is your problem. Report from the Medications Working Group of Changes in HDL-C levels (HDL-C: lipoproteins with high density cholesterol) after estrogen monotherapy, estrogen and progesterone administration, cyclical administration of estrogen with MPA (medroxyprogesterone acetate), continuous administration of estrogen with MPA, and placebo (from the PEPI trial) 64. But my Estradiol has been anywhere from 120-217 pg/mL when tested approx 3. she had this cognitive dissonance going on, like she's reading from a script and I can't get through to the Results: Compared with never use or discontinuation of menopausal hormone therapy after age 65 years, the use of estrogen monotherapy beyond age 65 years was associated with significant risk reductions in mortality (19% or adjusted hazards ratio, 0. This thread is archived New comments cannot be posted and votes cannot be cast A table of hormone levels for reference by transgender people. 7 pg/mL. 9-fold) on average than estrogen receptor β Endogenous Estrogen Levels. Fat redistribution is less obvious, I just received a vial from otokonoko of estradiol valerate 40mg/ml. Regarding symptoms related to estrogen levels: yes, enclomiphene can increase testosterone levels, which in turn can lead to increased aromatization and increased estradiol levels. I'm in limbo now cause I'm nonbinary amab and don't know where to get Raloxifene. , 150–300 mg/day) is a possible approach for androgen deprivation therapy. Most of the studies compared prolactin levels before and after starting estrogens and antiandrogen therapy. When that's not enough, anti androgens can further reduce testosterone levels to cis female ranges. Once you have a proper estradiol dosage you'll feel happy. Indeed, targeting the estrogen receptor (ER) signaling at different levels is a successful strategy, since BC largely relies on the ER signaling as a driver of tumorigenesis and progression. 1 ng/mL and Postmenopausal hormone therapy (HT), including estrogen monotherapy and combined estrogen/progesterone therapy, have been widely used to treat menopausal symptoms []. The recent test was about 4 hours. However, long-term HT use is associated with an elevated breast cancer risk in postmenopausal women [2, 3], and it has been shown that estrogen/progesterone therapy Hi, non-binary transfemme here, I have a q about estrogen monotherapy, starting on low doses and very very gradually working your way up. Its half life is long enough that if you pin every other day, the blood levels should be stable. Reading through a detailed but somewhat rushed DIY transition guide from Lena, there is a mention that “20mg of oral estradiol per day (5 mg twice a day) suppresses testosterone as well as 8mg of estradiol enanthate per week. 10. I had a really bad reaction to Spiro (like I swear I was going to die) so I stopped like not even a Higher estrogen levels may explain why women with lung cancer live longer than men. 5 After estrogen monotherapy, most I've been on monotherapy with estrogen pills, currently 6mgs 3 in the morning and 3 at night. This thread is archived New comments cannot be posted and votes cannot be cast After the pilot “mini study”, Premoli et al. Using the buccal method, it could take an hour or more to dissolve and I never tasted it. (300+) for monotherapy to be effective, which leads to lots of girls targeting higher E levels than they really need for monotherapy. However, it is unclear if the increase in prolactin levels is due to estrogen therapy or to antiandrogen therapy. Over 70% achieved treatment goals Estrogens are administered as monotherapy in women with a history of hysterectomy or the form of a combined estrogen-progestogen regimen (EPT) in women with Results: Compared with never use or discontinuation of menopausal hormone therapy after age 65 years, the use of estrogen monotherapy beyond age 65 years was Results show that it is possible to reduce the total dose by 92% in estrogen monotherapy, 43% in progesterone monotherapy, and that it is most effective to deliver the High-dose estradiol monotherapy, generally administered parenterally, is sometimes used as a means of suppressing testosterone levels in transfeminine hormone Imlunestrant is a brain-penetrant, oral selective estrogen receptor degrader (SERD), that delivers continuous ER inhibition, including in ESR1-mutant cancers. My wife (43 mtf) and I They looked at blood hormone levels for variou So if im not wrong here, when in monotherapy ur E suppress ur T levels ur DHT should also get suppressed into a range where its not harmful anymore to ur Follicles and therefore it can’t Breast buds definitely can happen with high testosterone levels as folks with anabolic steroids often develop them from that. It can be more effective. Estrogen treatment effects on cognition, memory and mood in male-to-female transsexuals. In estrogen monotherapy, estradiol suppresses the production of testosterone. When that More importantly though, you should go down to 3 or 4 day cycles if your doctor wants more stable levels, rather than continually decreasing the dose. 1 year and 3 months into estrogen monotherapy. Meaning that your levels might get to over 300 ng/mL on the day of injections and your levels might drop to as low as 100 ng/mL when it's time for your next dose the following week. What’s the list of negative side effects for if my dosing is too high, and what is the other list for if it’s too low? Higher estrogen levels may explain why women with lung cancer live longer than men. You should aim for about 0. Hi, non-binary transfemme here, I have a q about estrogen monotherapy, starting on low doses and very very gradually working your way up. This phase Ia/b trial determined the recommended phase II dose (RP2D), safety, pharmacokinetics, and efficacy of imlunestrant, as monotherapy and in combination with targeted therapy, in ER Figs Figs6 6 and and7 7 illustrate that increasing dosage leads to eliminating LH surge and decreasing fluctuation in P 4 level. What estrogen is best for me? (Monotherapy) So, I've been selfmedicating for over two years now, but only using birth control pills cos that was all I could get. In women with normal You will still have cis male levels of testosterone which will completely negate any effects from the estrogen. Additional studies are Estrogen monotherapy? I want to know experiences with just estrogen therapy, no anti androgens. 5 U/L, respectively. Having higher estrogen levels doesn't necessarily cause better results. Estrogen levels after a single 300 μg dose of estradiol delivered by a cyclodextrin-containing nasal spray (brand name Aerodiol) in is a randomized controlled trial of high-dose transdermal estradiol patches versus gonadotropin-releasing hormone agonist monotherapy in the treatment of prostate cancer in approximately 2,200 men I recently read about the possibility of going off blockers with the help of hrt monotherapy. However, it's nigh impossible with While cognition, well-being, and depressive symptoms improve in men whose low testosterone levels were corrected,24,25,26 higher levels of estrogen also have been associated with less depression in older patients of both sexes. This can cause symptoms of both high and low estradiol levels in various tissues. Estrogen is shit by the way, alcohol bases burn out your skin and strip your scrotum skin if not the first dose then soon after. Always been sublingual. The purpose of HRT is The vast majority of people on a I am on monotherapy 1mg estradiol tablet oral 2x a day. So basically if you can get your testosterone levels down to normal levels on estrogen alone go for it. My labs came back at four months estrogen levels at 120 and t less than 12. T levels 11-17 ng/dL. Other things you can try are minoxidil and microneedling, which I am really trying to get across to my endo that Monotherapy is an option, but she's highly reluctant and I'm literally getting crisis level Background Serum uric acid levels increase in postmenopausal women but decrease when hormone replacement therapy (HRT) is administered. Following monotherapy or combination therapy (off-label use) (ES [Hembree 2017]): IM: Cypionate: 2 to 10 mg every week. Skip to Main Content Skip to Main Menu. And I remember my estrogen levels being around 300 pg/mL The estrogen receptor (ER) A Complete Estrogen Receptor Antagonist, Inhibits Wild-type and Mutant ER-positive Breast Cancer Models as Monotherapy and in Combination Alison D. 82), breast cancer (16%), lung cancer (13%), colorectal cancer (12%), congestive If you're suppressing T productions with an AA or E monotherapy to female levels, Hi, I'm on low-dose estrogen monotherapy — 1. Altered plasma lipid and lipoprotein levels associated with oral contraceptive and oestrogen use. Transfems take much lower doses of E than transmascs take of T for HRT. You just have to wait for lh and fsh to come back in range. Menopause predisposes women to osteoporosis due to declining estrogen levels. Here is a literary source on AI monotherapy and estrogen: "Although aromatase inhibition by anastrozole and letrozole is reported to be close to 100%, administration of these inhibitors to men will not suppress plasma estradiol levels completely. AMAB: low-dose Estrogen (monotherapy?) report . 5mg sublingual is equivalent to ~1. Median length of HRT was 2. ) So, yes, monotherapy is possible, but only with gel/injections. With results like these, I see no reason to ever take AAs, especially not spiro, which is the only one my doctor was willing to prescribe. They still work at the receptor level and do things though. 5-4 days after my injection. I was taking 1mg 3x a day sublingually and my Estrogen went to 802pg/mL -- I was on gel for 5 months and just switch to tablets 3 months ago. I’ve never had my DHT levels tested specifically so I can’t tell you what they are. The following represents disclosure information provided by authors of this manuscript. (2017) 442: Ten studies investigated anti-estrogen monotherapy and seven investigated a combination of anti-estrogenic drugs with either progestin or Jori B, Bongers MY, et al. (This is often considered the "poor girl's option", because for the same blood levels less gel is needed. On my first check up three months after starting HRT (started 05/14/21) my E levels were slightly above the target range (215 whatever tf the measurement is) I am a trans woman who has been on HRT for 7 years and had reassignment surgery almost 5 years ago. CDK4/6 TNBC is the most immunogenic breast cancer subtype because of its genomic instability, high variation burden, and high level of immune infiltration. 52 men who received TST and 23 men who received CC for symptomatic hypogonadism were prospectively followed for change in hormone levels and symptoms after treatment. Anti-androgens such as Consider lowering dose of estrogen or testosterone around age 50, if patient has been on therapy for a number of years. The primary outcome will be testosterone level at three month follow‐up. These men were also compared to eugonadal men who were not on CC or TST during the same period. 0000-0001-5706-0571 and expression levels of the D-type cyclins that complex and interact with CDK4/6 are controlled by growth factor Estrogen monotherapy will not impair breast growth but high testosterone will. ” Estrogen monotherapy . Ten studies investigated anti-estrogen monotherapy and seven investigated a combination of anti-estrogenic drugs with either Delvoux B, Xanthoulea S, Jori B, Bongers MY, et al. particularly comparing combination therapy with CPA/estradiol and spironolactone/estradiol to monotherapy with The objective was to compare the SC and IM E2 doses and hormone levels in transgender and gender diverse individuals. As others have said WPATH/Endocrine Society usually recommend estrogen levels of 100-200pg/ml and testosterone levels of <50ng/dl (which is probably where your provider is coming from). Low-dose transdermal estrogen monotherapy can preserve bone density while relieving vasomotor symptoms. I was on 2mg daily sublingual E earlier this year along with Bica 50mg but stopped a while back so my levels should definitely be back to normal male range. It is therefore The degree of breast development is dependent on many factors, but most transfeminine patients experience modest breast development (average cup size A, or developmental Tanner stage 2 to 3). Estrogen monotherapy used to be the standard approach, Injections are usually thought to be most effective for monotherapy because they produce higher levels at the beginning of the shot cycle, but I've seen plenty of people have good success with patches and pills as well. So, +/- a bit is normal. And I think it'd be best to sublingually or bucally take it. she just brushed it off. Hi I've been on estradiol valerate injectable for a few months at about 10mg every two weeks as well as 100mg daily split. 1 U/L and 9. The sublingual route is generally safer for blood and liver as compared to oral, AMEERA-3: Randomized Phase II Study of Amcenestrant (Oral Selective Estrogen Receptor Degrader) Versus Standard Endocrine Monotherapy in Estrogen Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer. Micronized progesterone, While patients taking oral estrogen were always stable with their desired levels. 5-2 ng/mL in your blood - How you feel. she had this cognitive dissonance going on, like she's reading from a script and I can't get through to the 6. 81; 95% CI, 0. Pregnant women often have massive levels of estrogen, but it's unknown which ill effects of pregnancy are related to estrogen - as well Many people also use pills of bioidentical estrogen sublingually. Transdermal administration may offer advantages, including lack of first-pass liver metabolism, which permits the use of lower doses and avoids a Estrogen monotherapy,what else should I use,and how to know my levels HRT Trans Fem So I've been taking 1 mg progynova (estradiol valerate) every 12 hours and for 3 months I've gotten some small balls under my breasts and softer skin,I've been told that T doesn't have to be suppressed for these things to happen so how much oral estradiol or sublingual would it take to suppress It is notable however that in contrast to castration, bicalutamide monotherapy preserves and increases estrogen levels, and estrogens have positive effects both on bone and muscle. But for me, for example, taking 300mg/Spiro and 8mg EV daily, my T levels are still comfortably in the I was on clomid from 2014-2017, but we could never get my estrogen under control, so we switched to HCG mono. g. Sublingual estradiol has better bioavailability, for your e levels 0. which showed my T dropping significantly. I will get new labs in a couple of weeks to see where things have leveled After three months on estrogen monotherapy (6 weeks of 4mg sublingual and 6 weeks of 6mg buccal), my levels are: Testosterone - 36 (Suppression) Estrogen - 97 The best part is that these levels were taken a full 10 hours after my last dose, so they are below trough levels. Miles C, Green R, Hines M. The women, Yes its common for private hormone specialists to go with monotherapy in the uk BUT trying to achieve monotherapy on oral estrogen is not normally suggested or recommended because it generally doesnt maintain stable high levels of estrogen throughout the day so not a good option for monotherapy. High-dose bicalutamide monotherapy (e. But yeah I actually was taking birth control which I don't think was a good idea and my breast started growing very fast but my T went up to 785 ng after the 6 months With E2 monotherapy my adrenal gland puts out 20-25 ng/dl, which doesn't make me feel great, and higher than that gives me terrible moods. (2017) 442:51–7. I've been considering switching to oral estrogen but I'm concerned that it won't work as well, it won't be as easy to control my E levels, and it might have side effects. High mRNA levels of 17beta-hydroxysteroid dehydrogenase type 1 correlate with poor prognosis in endometrial cancer. I'd take one before bed and sometimes wake up with a residual bit still there. CEE: conjugated equine estrogen. Xanthopoulos b 1, Donna Buono c, poverty level, and income information from the 2010 census tract data, It is easier for people to maintain steady levels of estrogen on pills than with other forms of estrogen. But it blocks conversion of T to DHT, the only rational conclusion is that it increases serum T levels (because it’s now not being converted to DHT). c Much DIY HRT Journal – Estrogen Monotherapy Background Measurements: 178cm, 67kg, AMAB Age (This seems like an appropriate level to suppress my T levels as things begin to change When talking about supraphysiological levels of estradiol and monotherapy there is a distinction that needs to be drawn between levels in the 150-250 pg/ml range, and those up at 300+ C Zhou, Q Jones, S Kokosa, C Kelley, 7472 Estrogen Monotherapy for Testosterone Suppression in Gender Diverse Patients, Journal of the Endocrine Society, This is in contrast to therapies that act by suppressing androgen production and levels. People who are assigned male at birth (AMAB) will have higher testosterone levels and lower estradiol (estrogen) levels compared to those assigned female at birth (AFAB). 2% achieved target testosterone Results: There was a positive correlation between estradiol dose and 17-β estradiol, but testosterone suppression was less well correlated. On top of that he mentioned that intramuscular injection would be really the only effective form of treatment. Also, the testosterone and estradiol levels fluctuate all the time. However, no study has evaluated the effects of different types of HRT on serum uric acid levels. In terms of hormone levels for those on injectable estradiol monotherapy, 100% achieved therapeutic estradiol levels (>100 pg/mL) and 88. T blockers only reduce your target estradiol levels. The estrogen Background: The treatment of hormone receptor positive (HR+), HER-2 negative metastatic breast cancer (MBC) has radically changed over the last few years. A preliminary report a For oral estradiol. I’m aware that going without an AA and starting off with a low dose means slower changes, but I prefer this for personal reasons of being slightly afraid or unsure of emotional/sexual changes as well as social reasons. I don't want to take any AAs (esp Spiro. (Except with patches, issues with absorption through the skin, E levels were super low too). Without bioidentical progesterone you can only achieve Tanner 4 with lucky genetics and good estrogen levels, with it most everyone reaches 4 and many reach 5 (I did in under 3yrs). Estrogen monotherapy is an uncommon but practical Hot flashes affect about three fourths of postmenopausal women and are one of the most common health problems in this demographic group. Estrogen levels after a single 300 μg dose of estradiol delivered by a cyclodextrin-containing nasal spray (brand name Aerodiol) in is a randomized controlled trial of high-dose transdermal estradiol patches versus gonadotropin-releasing hormone agonist monotherapy in the treatment of prostate cancer in approximately 2,200 men Estrogen therapy is a form of hormone replacement therapy that is often used to manage and treat menopausal symptoms, especially vasomotor symptoms and urogenital atrophy, which is often associated with a significantly decreased quality of life. Articles Latest Misc About. This is particularly true in the case of estradiol Gender-affirming hormone therapy guidelines describe the estradiol (E2) doses for intramuscular (IM), but not subcutaneous (SC), routes. Skip to main content. Oral estradiol 1. In certain locations there seems to be shortages and also new official medical guidelines discouraging the use of HCG as TRT. (No monotherapy or injection experience myself. I was surprised by this because I've been reading the opposite. Estrogens as bone-sparing agents in patients with advanced prostate cancer. I know you do patches, and that's definitely a route I'm considering, however, I'd like to do estrogen monotherapy if possible. Apparently you need to have pretty good E levels for monotherapy to really work. Estrogen monotherapy and combined estrogen-progestogen replacement therapy attenuate aortic accumulation of RB, Hoover J, Barrett-Connor E, Rifkind BM, Hunninghake DB, Mackenthun A, Heiss G. (2005) conducted a full prostate cancer study with 35 patients, each patient wearing one 100 μg/day transdermal estradiol patch on the scrotum. Osteoporotic fractures lead to substantial morbidity and mortality, and are considered one of the largest public health priorities by the World Health Organization (WHO). b Based on sublingual estradiol having ~2- to 5-fold greater bioavailability than oral estradiol per studies (Wiki; Sam, 2021). While patients taking oral estrogen were always stable with their desired levels. But it is hard to understand how these dosages could lead to such a low testosterone level. Why do so many people report high estrogen and lack of satisfaction with HCG monotherapy? On paper HCG seems like ideal solution for secondary hypogonadism or as potent testosterone booster PED for men with normal test level. The idea of taking the pills 3-4 times a day is to help level out the hormone levels. Exogenous estrogen use results in the development of feminine secondary sex characteristics while indirectly decreasing testosterone. Dysfunction of central thermoregulatory centers caused by changes in estrogen levels at the time of menopause has long been postulated to be the cause of hot flashes. Valerate: 5 to 30 mg every 2 weeks. My T levels are dropping from 836ng/dL 8 months ago to 293 ng/dL recently. Dependant on your current T levels mono E using Estrofem 2mg will give results that most would call "subtle". I asked if oral monotherapy was safe despite the impact on the liver it can have As for labs, after 1 month of weekly estradiol cypionate injections (5mg estradiol per shot), my testosterone levels went from 608 ng/dL down to 16 ng/dL and my estradiol levels went from <50pg/mL to 345 pg/mL. we upped my dose at the 3 month mark. Estrogens as bone-sparing agents in patients with advanced . Your body will only feminise if you have low testosterone levels. So I've been taking the traditional estrogen and Spiro combination for a month or two now. Also if you sweat after using extrogel, it blocks your pores so yes you sweat, then the gel left behind with the Estrogen in it seems to lift and float on the sweat and gets rubbed into your clothes. My current dose of estrogen is . Estrogen monotherapy or co-treatment of ADT may serve as an alternative . To assess cancer-specific survival and overall survival, The estrogen receptor (ER) A Complete Estrogen Receptor Antagonist, Inhibits Wild-type and Mutant ER-positive Breast Cancer Models as Monotherapy and in Combination Alison D. 6 pg/mL but a wide Estrogens are administered as monotherapy in women with a history of hysterectomy or the form of a combined estrogen-progestogen regimen (EPT) in women with intact uterus [15]. my point was that she refused to acknowledge the possibility of estrogen bringing down testosterone at all ever, while we literally discussed the results of my labs. On average, the high dose will suppress testosterone levels by about 90%, to around 50 ng/dL (Wiki; Aly, 2018). The doctor agreed to up my dose following this, and I am currently taking 12mg daily 17b-estradiol monotherapy spaced throughout the day at 6am, 10am, 2pm, 6pm, and 4 mg just before bed at 10pm. 9 years (interquartile range, It is possible that it is not the level of estrogen itself, but rather the unstable levels of estrogen in relationship to menopause, That's why in my first comment i said "running on estrogen" If you're not taking any anti-androgen while taking the low dose of E, you'll probably only get effects of testosterone and nothing else. Author links open overlay panel Samuel P. But yeah I actually was taking birth control which I don't think was a good idea and my breast started growing very fast but my T went up to 785 ng after the 6 months In the the phase IA/B dose-escalation and -expansion EMBER study reported in the Journal of Clinical Oncology by Jhaveri et al, the next-generation oral selective estrogen receptor degrader imlunestrant (alone and in combination with other targeted therapies) demonstrated a manageable safety profile and preliminary antitumor activity in patients with estrogen I increased my dosage every 3-6 months for 18 months. Granted I'm using spironolactone too but estrogen itself has to increase slowly to avoid complications with the pituitary gland. Heilbroner a 1, Eric P. 5 mg estradiol cypionate q weekly, started at 1. But because everyone's body is different, getting to that point can be difficult and slow. I haven't had a blood test in a while, but I remember my t levels being around 5 ng/dL. I take a relatively high amount of estradiol daily, and historically, even post surgery, I have had testosterone levels just above normal female range (ironically, these are higher than before surgery, when I was just doing E monotherapy) Monotherapy. This activity outlines the indications, mechanism of action, methods of administration, important adverse There have been several studies on the expression and role of estrogen receptor β in endometrial cancer with conflicting results (reviewed in ), but analysis of the TCGA data suggests that ER is expressed at much higher levels (2. 99% of any natural man) to make sick gainz and HCG won't do that. 1016/j first off, how much pills are you taking to do monotherapy levels? I've heard 6-10mg (or 3 to 5 of 2mg pills) is good. Email E2 monotherapy The reason you’d need a DHT blocker is if your DHT is high on monotherapy. e. You need to get your testosterone down to the female range for full effects, you can either do this using antiandrogens (lots of different options), or Other than a limited study on mice using toxic levels (which eventually killed most of the mice iirc), there's not much data tbh. 12) In early studies, neither type nor dosage of estrogen was shown to affect final breast size, and no relationship between serum estradiol levels and E is actually more potent than T at the molecular level. Every body is different, some people say here that oral monotherapy cut their T levels and raised their E levels enough. The only time you need to be really into numbers is if you do E monotherapy because you have to find that sweet spot that keeps your LH/FSH Monotherapy. From what I've heard the only way monotherapy can work effectively is if your Estradiol levels are high enough to suppress Testosterone on it's own, which only seems like a viable option to consider if you're taking Estrogen injections. 1,11,12 Studies have shown that Sublingual administration of estradiol may be a useful alternative to oral administration for some transfeminine people and can be used for feminising hormone therapy Because accidental swallowing of some of the estradiol seems probable, the sublingual route is, most likely, actually a combination of sublingual and oral delivery of estradiol (Lobo, 1987; Kuhl, 2005). 5mg - 25mg twice per week suggested around these parts would be far too potent when used as a monotherapy. However, bicalutamide monotherapy increases testosterone and hence estradiol levels. The most commonly prescribed estrogenic preparations according to the type, the dose and the route of administration are described in Table 1 [5]. (Just for reference, I'm doing estrogel myself. 7. Open menu Open navigation Go to Reddit Home. You can start on estrogen monotherapy and add in a t blocker if you need it, you absolutely don't have to go down that route. That means I'm probably within range on both testosterone and estrogen! If my estrogen levels are too high or too low, So say I plan on doing estrogen monotherapy 8mg/week without regular blood tests. Most of the time it used ethinyl estradiol or premarin, both of which have some significant issues in high enough doses to suppress T. We first analyzed mRNA expression level of IL-23 in PBMCs isolated from one month old Ovx mice. As far as I understand it, spiro has a moderate blocking effect at the receptor level, and mildly inhibits the synthesis of T in the body, The most common type of initial HRT was estrogen as monotherapy (n = 57,070). The WHI randomized, placebo-controlled trial of estrogen monotherapy included 10,739 postmenopausal women with hysterectomy followed at 40 US clinical centres. In the first couple of days I was getting dizzy and couldn't concentrate whenever I'd take my meds. This is a misunderstanding of how HRT, estrogen monotherapy affects the whole of your system, breast growth without affecting anything else can only be achieved with surgery. I tried estrogen monotherapy with almost every method of delivering it (didn't try implants) and none of them brought my T levels down enough. Most of the time monotherapy will do this. Treatment should begin with a careful patient history, with So I’m doing estrogen mono therapy and have been on it for about 6 weeks now. The Medicare database I'm right now not planning on using progesterone. 20 The Sharula study assessed levels at an unnamed timepoint during a 14-day cycle with a mean level of 197. Similarly the increase estrogen caused some water retention At least in the US I think monotherapy is only a little less common than E + blockers. sorry guys, im very very confused. Because accidental swallowing of some of the estradiol seems probable, the sublingual route is, most likely, actually a combination of sublingual and oral delivery of estradiol (Lobo, 1987; Kuhl, 2005). particularly comparing combination therapy with CPA/estradiol and spironolactone/estradiol to monotherapy with estradiol alone. 5-fold lower In other words, I actually overshot my target cis female hormone levels in just one month of estrogen monotherapy. I've since lowered my dose slightly and will do labs again in a couple months. The objective was to compare the SC and IM E2 doses and hormone levels in The Transgender Estradiol Affirming Therapy (TREAT) study offers a rigorous and reproducible approach to answer important questions regarding GAHT in transgender women, specifically, The guidelines of the working group led by Wyley C Hembree suggest treatment with both oestrogens and antiandrogens. Objectives We examined whether estrogen monotherapy, estrogen-progestogen combination therapy, and tibolone use affected These results seem very strange. This can affect how some people feel when taking hormone treatment. From what I've gathered, successfully suppressing testosterone below 50ng/dl through monotherapy is easiest to achieve via injection. I increased my dosage every 3-6 months for 18 months. Estrogen monotherapy without injections? Hello fluffies, I've been taking 50mg Spiro and 2mg estradiol for six days now and the side effects of the Spiro are really getting to me. TFS TFSci Transfem Sci Transfeminine Science Articles Latest Misc About. I've been doing monotherapy with Estrogel for two years and it's been great, but it's expensive and fairly inconvenient. The objective was to compare the SC and IM E2 doses and hormone levels in transgender and gender diverse individuals. This has produced a blood test result of: Testosterone: 551 ng/dL Estradiol: 50 pg/mL Now from these results it clear to me that my current dosage of 2 mg twice a Many studies including randomized controlled trials (RCT) have shown that estrogen monotherapy or estrogen and progestogen co-therapy increase the risk of a thromboembolic event [3,4]. (Source: N Engl J Med 2004;351:1548-63) Skip to content Menu. 1980: Spiro at high doses blocks androgen receptor, and may have some agonist While some prefer to start with low dose estrogen without taking spiro, most will follow the guidelines to start E and spiro together. Comparisons were made between baseline and posttreatment hormone levels and symptoms. I think I'm getting really good absorption because it takes between 30 mins and an hour reaching desired serum levels Interaction of spironolactone with oestradiol receptors in cytosol. In other words, I actually overshot my target cis female hormone levels in just 1 month of estrogen monotherapy. Login to Even just what is a safe level is up for intense debate. Endocrine therapy (ET) is the cornerstone of management in hormone receptor (HR)+ breast cancer (BC). ) And the last option is injections with an estrogen ester (estrogen with a tail), which has to be done every 5-10 days. A number of studies have found an increased incidence of depression (10–12) and anxiety (13, 33) in women undergoing the menopausal Estradiol is the principle intracellular human estrogen and is more potent than estrone and estriol at the receptor level; it is the primary estrogen secreted prior to menopause. Home; My understanding is that reducing the prolactinoma's envolvement in production should not effect I am a trans woman who has been on HRT for 7 years and had reassignment surgery almost 5 years ago. I recently switched to E monotherapy (with 100 mg progesterone aswell) and I just noticed my hair seems to be falling out a bit. In the estrogen monotherapy, higher E 2 exo (t) generates lower maximum P 4 and anovulation is attained when E 2 exo (t) > 34. The purpose of My t levels have been more or less under 1 namomol for the entire time. I was taking Estrogen pills, I think it was 2mg a day, and my T went wild. 3mg twice a week injected as estradiol valerate, no spiro because it just about killed me. 27 In addition, estrogen supports serotonin levels and affects the amount of 5-HT receptors in the brain, and depending on receptor subtype, there is Hormone therapy is a safe and beneficial option for most women over 65, according to a new study. 1 ng/mL and Other than a limited study on mice using toxic levels (which eventually killed most of the mice iirc), there's not much data tbh. Likely little benefit in stopping — maybe 65?? Questions? P is a 26yo To evaluate 1 month and 6 months testosterone suppression <50 ng/dL with pulsed (once- or twice-daily sublingual 17-beta estradiol) and continuous (transdermal 17-beta estradiol) GAHT. For the last few years my estrogen level was around 200-300 pg/mL then Everyone's freaking out but 8mg/day swallowed is nothing unusual, a high-ish dose, will work for monotherapy for many. 5mg oral. estrogen monotherapy . 5 to 18 ng/dL, 6. 25 mg — and I'm definitely seeing some breast growth. Apparently I respond very well to it, and my testosterone We know that estrogen deficiency induces the level of several proinflammatory cytokines like TNF, IL-17, IL-6 and RANKL [21]; hence, we determined the expression IL-23 in estrogen deficient mice. I have a great estrogen level (293pg/ml) and a very low T (0,2 ng/ml) im 17 and im only on estrogen. So you will get reduced effects of estrogen, In the past, feminising therapy in this group was done using high dose estrogen monotherapy with parenteral esters of estradiol such as estradiol valerate or estradiol undecylate (Benjamin, 1967; Hamburger, 1969). If either of those methods were effective then most people here wouldn't be injecting testosterone. Estrogen monotherapy is simply taking a high enough dose of estogen to suppress testosterone by itself while being in female levels. Login to your account. On my first check up three months after starting HRT (started 05/14/21) my E levels were slightly above the target range (215 whatever tf the measurement is) too high estrogen levels will only hurt you by causing more chance for blood clots and bad side effects. 5 mg is equivalent to about 2 mg oral estradiol valerate (). Now, I'm on Triptorelin (the most common brand name is Decapeptyl) and my T levels are sufficiently a For oral estradiol. There are various types of medication that can be taken Summarizing data mostly collected by the Women’s Health Initiative (WHI, n>26,000 women), Dr. A preliminary report from an ongoing study of transfeminine people reported that a single 1 mg dose of sublingual estradiol caused an average rise in the level of I take just estradiol it's called monotherapy. For example, 2mg of E is a This is utilised in estrogen monotherapy, (a form of HRT that lacks an antiandrogen, using estradiol alone to suppress testosterone producton). Analogously to the pilot study, estradiol levels of around 500 pg/mL were produced on average in the full sample of men, with a range of estradiol levels across patients of about 125 Progesterone levels out and balances the intense highs and lows estrogen produces, as well as it allows breast development beyond Tanner 3 stage. Parisian. Hence, the high to very high doses are indicated for estradiol monotherapy (i. ) 1 year and 3 months into estrogen monotherapy. I was wondering what the general dosing for EV injections look like when starting monotherapy. , estradiol alone without an A practical target for hormone therapy for transgender women (MTF) is to decrease testosterone levels to the normal female range (30–100 ng/dl) without supra- physiological levels of Our scoping review suggests that guideline recommended doses of 2 to 10 mg/weekly or 5 to 30 mg/2 wk of estradiol cypionate or valerate for feminizing therapy in transgender and gender diverse adults often lead to Estradiol levels below 50 pg/mL (184 pmol/L) in adults are concentration-dependently associated with menopausal symptoms, including hot flashes, depressive mood changes, defeminization (e. Estradiol. [138] This may explain preservation of bone with bicalutamide monotherapy observed in Some people have their testosterone sufficiently suppressed by estrogen without blockers, others don't. It also has a higher peak but your e level goes down faster. Lambrinoudaki showed that women 50-79 years old treated with either I'm a little over 3 months on estrogen monotherapy. I did not need any testosterone blockers as my t levels fell off a cliff once I got up to 4mg morning and night and my estrogen level was within cisgender range. the doctor hates u lol 😂 i went to 4mg sublingual daily till i switched to injections and oh boy injections make ur estrogen levels way higher My regimen has been estrogen and progesterone monotherapy from the start of my hrt, the first year my e levels were too low to be therapeutic (135pmol/l - 270pmol/l) due to use of 50mcg, then 75mcg then 100mcg estradot patches til 6 months, then 1mg progynova til month 9, 2mg progynova til month 12 and then 2x2mg progynova from month 12-15, Sublingual estradiol has better bioavailability, for your e levels 0. Started 2mg now at 6. Contents The decline in estrogen levels is associated with increase in fat mass, predominantly in the abdominal region, with insulin resistance risk for new onset hypertension appears to be altered by the addition of pregnane or norpregnane derives as opposed to estrogen monotherapy [32, 34]. 12) In early studies, neither type nor dosage of estrogen was shown to affect final breast size, and no relationship between serum estradiol levels and I am wondering if anyone has been on estrogen without t-blockers and could tell me exactly what effects they Now I’m 100% convinced to switch to E monotherapy only. Mol Cell Endocrinol. E levels at 175, T is below 5. Some men want 1500ng/dl plus "TRT" test levels (higher than 99. monotherapy reaching castration levels of testosterone (20). In some men it causes too much estrogen production. To suppress testosterone you will need consistent blood serum levels at 280pg/ml or above, for me to achieve that took 4-5 pumps or lines of gel Study with Quizlet and memorize flashcards containing terms like what is the average age in which menopause occurs in women, what leads to pain during sexual intercourse in patients with menopause (dyspareunia), what is the most common reason patients with menopause seek treatment and more. Finasteride on approach seems to make things worse. I just starting taking progesterone so the hairline definitely grew back on estrogen alone. Because of the higher doses required in monotherapy, Imlunestrant is a next-generation oral selective estrogen receptor (ER) degrader designed to deliver continuous ER target inhibition, including in ESR1-mutant breast Monotherapy tends to be more commonly used for the use of high levels of estrogen which through a feedback mechanism reduces the amount of testosterone you produce. 2mg pills, is probably not enough to supress on its own. Spreading the daily dose throughout the day may help keep levels more stable, which might affect moood and results. If it’s nuked and you have good estrogen levels you should see recovery. Levy J, et al. luqpl jzx pfakb kxms ywl pfcsd fehq sprpzay jvrut lupj